Statistics
| Player | 1st Yr | L Yr | W | Player | 1st Yr | L Yr | Sv | |||
| Ferrell,Wes | 1928 | 1940 | 193 | Wilhelm,Hoyt | 1957 | 1972 | 177 | |||
| Cone,David | 1988 | 2001 | 174 | Street,Huston | 2006 | 2017 | 120 | |||
| Zachary,Tom | 1921 | 1934 | 156 | Beck,Rod | 1992 | 2000 | 100 | |||
| Shantz,Bobby | 1950 | 1965 | 140 | Sambito,Joe | 1978 | 1982 | 97 | |||
| Buehrle,Mark | 2001 | 2012 | 139 | Urbina,Ugueth | 1999 | 2006 | 83 | |||
| Orth,Al | 1902 | 1910 | 136 | Myers,Randy | 1988 | 1992 | 71 | |||
| Cole,Gerrit | 2014 | 2023 | 131 | Miller,Andrew | 2016 | 2019 | 60 | |||
| Law,Vern | 1956 | 1968 | 126 | Downs,Scott | 2009 | 2011 | 55 | |||
| Palmer,Jim | 1970 | 1976 | 125 | Shantz,Bobby | 1950 | 1965 | 50 | |||
| Hoeft,Billy | 1953 | 1967 | 112 | Labine,Clem | 1956 | 1963 | 47 | |||
| Player | 1st Yr | L Yr | ShO | Player | 1st Yr | L Yr | K | |||
| Palmer,Jim | 1970 | 1976 | 37 | Cone,David | 1988 | 2001 | 2415 | |||
| Ferrell,Wes | 1928 | 1940 | 30 | Cole,Gerrit | 2014 | 2023 | 2120 | |||
| Buehrle,Mark | 2001 | 2012 | 30 | Buehrle,Mark | 2001 | 2012 | 1474 | |||
| Cole,Gerrit | 2014 | 2023 | 21 | Lolich,Mickey | 1966 | 1972 | 1408 | |||
| Law,Vern | 1956 | 1968 | 21 | Palmer,Jim | 1970 | 1976 | 1270 | |||
| Lolich,Mickey | 1966 | 1972 | 21 | Ferrell,Wes | 1928 | 1940 | 1200 | |||
| Webb,Brandon | 2004 | 2009 | 21 | Shantz,Bobby | 1950 | 1965 | 1176 | |||
| Cone,David | 1988 | 2001 | 20 | Hoeft,Billy | 1953 | 1967 | 1170 | |||
| Hoeft,Billy | 1953 | 1967 | 20 | Siebert,Sonny | 1965 | 1975 | 1152 | |||
| Three tied with | 1901 | 2023 | 19 | Stroman,Marcus | 2017 | 2023 | 1142 | |||